• Location

    Hertfordshire, England

  • Sector:

    Life Sciences

  • Job type:


  • Salary:


  • Contact:

    Denise Saab

  • Contact email:

  • Job ref:


  • Published:

    over 1 year ago

  • Expiry date:


  • Start date:


The Company's next-generation AAV gene therapy platform, we are seeking a scientifically and operationally strong Toxicologist with sound experience of early Phase translational research, who can lead CROs and external collaborators to deliver successful IND enabling studies supporting the company programmes.


  • Strong scientific background in Pharmacology and Toxicology to address key pharmacologic scientific questions, advancing projects from pre-clinical to early phase clinical development

  • Strong understanding of and experience with GLP toxicity requirements across different territories (e.g. EU, USA)

  • Understanding of the necessary preclinical data for a lead candidate to support IND/CTA, coupled with experience of working in cross-functional teams to support pre-IND drug development.

  • Ability to represent the company and strong experience working with external providers such as contract research organisations (CROs) and academic specialty laboratories.

  • Ability to direct and assess the work of a CRO to produce a high standard of work for ex-vivo and in vivo experiments

  • Exceptional analytical and problem-solving skills, with the ability to understand and interpret findings and to develop mitigation strategies for the successful progression of projects.

  • Willingness to travel both within the United Kingdom and abroad to evaluate capability of CRO and academic speciality Laboratories, support Regulatory meetings, as well as to present at conferences/workshops and other meetings


  • BSc in a relevant biological discipline or equivalent level of professional qualifications, with a minimum of 5 years of experience working in the pharmaceutical industry in a preclinical R&D environment

  • Experience with in vivo models in multiple species (rodent and non-rodent), as well as correlating in vitro/in situ systems with in vivo models

  • Has successfully led multiple GLP-toxicity studies, including protocol writing, study management and reporting

  • Excellent verbal and written communication and computer literacy skills, with the ability to write and present clearly and succinctly for regulatory documents, publication, for internal decision making

  • Personable and effective communicator, willingness to work as part of a multi-disciplinary team, to be open-minded, flexible and cooperative in a dynamic and fast-growing company



  • Prior knowledge on the execution of preclinical AAV studies using various in vivo model systems related to AAV gene therapy development to deliver high-value data and support all aspects of AAV-based gene therapy projects.